Clinical Edge

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Menstrual Bleeding & Rates of Amenorrhea

Contraception; ePub 2016 Jun 27; Mejia, Mcnicholas, et al

Following 12 months of levonorgestrel intrauterine system (LNG-IUS) use, women with heavier menstrual bleeding are less likely than women with moderate flow to report amenorrhea. This according to a secondary analysis of 1,802 continuous 12-month IUS users from the Contraceptive CHOICE Project, intended to evaluate the effect of baseline bleeding patterns on rates of amenorrhea reported at 12 months in LNG (52 mg) IUS users. Researchers found:

• Amenorrhea was reported by 4.9%, 14.8%, and 15.4% of participants at 3, 6, and 12 months, respectively.

• Higher rates of amenorrhea at 3 and 6 months post-insertion were reported by participants with light baseline or short duration of flow.

• However, LNG-IUS users with heavy or prolonged flow were less likely to report amenorrhea at 3 and 6 months.

• Participants with self-reported heavy bleeding at baseline were less likely to report amenorrhea at 12 months vs those who reported moderate bleeding (aOR, 0.36).

Citation: Mejia M, Mcnicholas C, Madden T, Peipert JF. Association of baseline bleeding pattern on amenorrhea with levonorgestrel intrauterine system use. [Published online ahead of print June 27, 2016]. Contraception. doi:10.1016/j.contraception.2016.06.013.