Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Intrauterine Device Use and HPV Infection

Am J Obstet Gynecol; ePub 2016 Dec 13; Averbach, et al

Women using an intrauterine device are not at increased risk for acquisition or persistence of human papillomavirus (HPV) infection, a recent study found, and device use is safe among women with HPV infections and at risk for HPV acquisitions. This according to a cohort study of 676 sexually active young women from October 2000 to June 2014 that evaluated the association between intrauterine device use and cervical high-risk HPV acquisition and clearance. Researchers found:

  • 85 women used an intrauterine device at some time during follow-up.
  • Among 14,513 study visits, women reported intrauterine device use at 505 visits.
  • After adjusting for behavioral confounders, there was no association observed between intrauterine device use and/or HPV acquisition (HR, 0.50) or clearance of HPV infection (HR, 1.44).


Averbach SH, Ma Y, Smith-Mccune K, Shiboski S, Moscicki AB. The effect of intrauterine devices on acquisition and clearance of human papillomavirus. [Published online ahead of print December 13, 2016]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2016.11.1053.