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Hormonal Factors and Endometrial Cancer

Risk evaluation in Lynch syndrome

Some endogenous and exogenous hormonal factors were associated with a lower risk of endometrial cancer in women with a mismatch repair gene mutation or Lynch syndrome and these associations were similar to those for the general population, according to a cohort study of 1,128 women. The study also found:

• 133 women were diagnosed with endometrial cancer.

• 11% of women with age at menarche ≥13 years were diagnosed with endometrial cancer compared with 12.6% of women with age at menarche <13 years.

• 10.8% of parous women were diagnosed with endometrial cancer compared with 14.4% of nulliparous women.

• 8.7% of women who used hormonal contraceptives ≥1 year were diagnosed with endometrial cancer compared with 19.2% of women who used contraceptives <1 year.

Citation: Dashti SG, Chau R, Ouakrim DA, et al. Female hormonal factors and the risk of endometrial cancer in Lynch syndrome. JAMA. 2015;314: 61-71. doi:10.1001/jama.2015.6789.