Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Emergency Contraception and Safety

A look at EC pills and their safety

Serious adverse events were rare among women taking levonorgestrel (LNG), ulipristal acetate (UPA), or Yuzpe combined oral contraceptives, in a study of women using these emergency contraceptive pills. When compared with women not taking emergency contraception pills, researchers found:

• Poor pregnancy outcomes were rare among pregnant women repeatedly using LNG ECPs.

• Poor pregnancy outcomes were rare among pregnant women who used LNG or Yuzpe ECPs during the conception cycle or early pregnancy.

• Breastfeeding outcomes did not differ between women exposed to LNG ECP and those unexposed, and there was no increased risk of ectopic pregnancy vs intrauterine pregnancy after repeated use of LNG ECPs vs non-use.

Citation: Jatlaou TC, Riley H, Curtis KM. Safety data for levonorgestrel, ulipristal acetate and Yuzpe regimens for emergency contraception. [Published online ahead of print November 3, 2015]. Contraception. doi: 10.1016/j.contraception.2015.11.001.