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SMFM Statement: Prenatal Acetaminophen Use in Children

Am J Obstet Gynecol; ePub 2017 Jan 17; SMFM Pub Committee

The Society for Maternal-Fetal Medicine (SMFM) has issued a statement on prenatal acetaminophen use and outcomes in children. The SMFM publications committee reviewed 2 new retrospective cohort studies published in the last year then examined an association between prenatal acetaminophen use and increased risk for adverse neurological outcomes in childhood. After reviewing these studies, the committee concluded:

  • The weight of evidence is inconclusive regarding a possible causal relationship between acetaminophen use and neurobehavioral disorders in the offspring.
  • Therefore, SMFM continues to advise that acetaminophen be considered a reasonable and appropriate medication choice for the treatment of pain and/or fever during pregnancy.


Society for Maternal-Fetal Medicine (SMFM) Publications Committee, SMFM Statement: Prenatal acetaminophen use and outcomes in children. [Published online ahead of print January 17, 2017]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2017.01.021.