Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Beginning estrogen soon after menopause slows atherosclerosis progression

Key clinical point: Waiting more than a decade after menopause to begin estrogen therapy did not provide heart-health benefits.

Major finding: Oral estrogen therapy taken within 6 years after the onset of menopause significantly reduced progression of lipid deposition in the carotid artery wall.

Study details: A secondary analysis of 643 women who participated in the Early Versus Late Intervention Trial With Estradiol.

Disclosures: The National Institute on Aging funded the study. Dr. Karim reported having no financial disclosures.


Karim R et al. Epi/Lifestyle 2020, Abstract MP09.