Clinical Edge

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Screening Mammographies in Premenopausal Women

Comparing annual vs biennial screening

Premenopausal women diagnosed as having breast cancer following biennial vs annual screening mammography are more likely to have tumors with less favorable prognostic characteristics, according to a study of 15,440 women ages 40 to 85 years with breast cancer diagnosed within 1 year of an annual or within 2 years of a biennial screening mammogram. Researchers found:

• Among premenopausal women, biennial screeners had higher proportions of tumors that were stage IIB or higher, size greater than 15 mm, and with any less favorable prognostic characteristic vs annual screeners.

• Among women currently taking postmenopausal hormone therapy (HT), biennial screeners tended to have tumors with less favorable prognostic characteristics compared with annual screeners; however, differences were not statistically significant.

• The proportions of tumors with less favorable prognostic characteristics were not significantly larger for biennial vs annual screeners among postmenopausal women not taking HT.

Citation: Miglioretti DL, Zhu W, Kerlikowske K, et al. Breast tumor prognostic characteristics and biennial vs annual mammography, age, and menopausal status. [Published online ahead of print October 20, 2015]. JAMA Oncol. doi: 10.1001/jamaoncol.2015. 3084.