Clinical Edge

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Mammographic Calcifications & Breast Ca Prognosis

Cancer; ePub 2016 Sep 28; Nyante, Lee, et al

Mammographic calcifications were associated with both unfavorable (high grade) and favorable (small size, hormone receptor positivity) prognostic factors in a recent study that included 8,472 invasive breast cancers diagnosed in the Carolina Mammography Registry between 1996 and 2011. Information regarding calcifications occurring within 2 years of diagnosis was reported. Researchers found:

  • The presence of calcifications was positively associated with tumors that were high grade or had an in situ component.
  • Calcifications were inversely associated with hormone receptor-negative status, and lobular tumors.
  • The association between the presence of calcifications and an in situ component was limited to BI-RADS category 4 and 5 calcifications and was absent for BI-RADS category 2 or 3 calcifications.
  • The association with tumor size was strongest for BI-RADS categories 3 and 4.


Nyante SJ, Lee SS, Benefield TS, Hoots TN, Henderson LM, The association between mammographic calcifications and breast cancer factors in a population-based registry cohort. [Published online ahead of print September 28, 2016]. Cancer. doi:10.1002/cncr.30281.