Clinical Edge

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Identifying Women at Risk for Epithelial Ovarian Ca

Defining a risk classifier

Both CA125 and HE4 tests contributed significantly to a risk prediction classifier combining serum markers with epidemiologic risk factors that may be useful in identifying post-menopausal women who would benefit from timely surgical intervention to prevent epithelial ovarian cancer, according to an analysis using 74,786 Women’s Health Initiative (WHI) Observational Study (OS) participants. Details included:

• In the WHI OS population, serum markers and epidemiologic factors classified 13% of women as elevated risk and identified 30% of ovarian cancers (HR=2.6).

• In the WHI Clinical Trial validation population, 8% of women were classified as elevated risk, identifying 31% of cancers (HR=4.6).

Citation: Urban N, Hawley S, Janes H, et al. Identifying post-menopausal women at elevated risk for epithelial ovarian cancer. Gynecologic Oncology. [Published online ahead of print September 3, 2105]. doi: 10.1016/j.ygyno.2015.08.024.