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Genetic Variants at Menopause and Ovarian Failure

Menopause; ePub 2017 Jan 23; Homer, et al

In premenopausal breast cancer survivors, 13 previously identified genetic variants associated with time to natural menopause were not related to timing of ovarian failure, a recent study found. This cohort of 169 premenopausal breast cancer survivors (median age 40.5 years; 69% white, 76% underwent chemotherapy) was recruited at diagnosis with stages 0 to III disease and genotyped for 13 single-nucleotide polymorphisms (SNPs) found to be associated with age at natural menopause: EXO1, TLK1, HELQ, UIMC1, PRIM1, POLG, TMEM224, BRSK1, and MCM8. Researchers found:

  • 38 (22%) participants experienced ovarian failure.
  • No candidate SNP was associated with time to ovarian failure.
  • Older age, chemotherapy exposure, and lower body mass index (BMI) were related to shorter time to ovarian failure.

Citation:

Homer MV, Charo LM, Natarajan L, et al. Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors. [Published online ahead of print January 23, 2017]. Menopause. doi:10.1097/GME.0000000000000817.