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Genetic Variants at Menopause and Ovarian Failure

Menopause; ePub 2017 Jan 23; Homer, et al

In premenopausal breast cancer survivors, 13 previously identified genetic variants associated with time to natural menopause were not related to timing of ovarian failure, a recent study found. This cohort of 169 premenopausal breast cancer survivors (median age 40.5 years; 69% white, 76% underwent chemotherapy) was recruited at diagnosis with stages 0 to III disease and genotyped for 13 single-nucleotide polymorphisms (SNPs) found to be associated with age at natural menopause: EXO1, TLK1, HELQ, UIMC1, PRIM1, POLG, TMEM224, BRSK1, and MCM8. Researchers found:

  • 38 (22%) participants experienced ovarian failure.
  • No candidate SNP was associated with time to ovarian failure.
  • Older age, chemotherapy exposure, and lower body mass index (BMI) were related to shorter time to ovarian failure.


Homer MV, Charo LM, Natarajan L, et al. Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors. [Published online ahead of print January 23, 2017]. Menopause. doi:10.1097/GME.0000000000000817.