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The Effect of Age on Breast Cancer Survival

J Clin Oncol; ePub 2016 Aug 1; Partridge, Hughes, et al

The effect of age on survival of women with early breast cancer appears to vary by breast cancer subtype, and young age may be particularly predictive in women with luminal breast cancers. This according to a study of 17,575 women with stage I to III breast cancer among whom 1,916 were aged ≤40 years at diagnosis. Median follow-up was 6.4 years. Researchers found:

• Women aged ≤40 years at diagnosis had greater breast cancer mortality (HR, 1.4).

• In stratified analysis, age ≤40 years was associated with statistically significant increases in risk of breast cancer death among women with luminal A (HR, 2.1) and luminal B (HR, 1.4) tumors.

• Age ≤40 years had borderline significance, however, among women with triple-negative tumors (HR, 1.4) but not among those with human epidermal growth factor receptor 2 subtypes (HR, 1.2).

• An additional model controlled for detection method showed young age was associated with significantly increased risk of breast cancer death only among women with luminal A tumors.

Citation: Partridge AH, Hughes ME, Warner ET, et al. Subtype-dependent relationship between young age at diagnosis and breast cancer survival. [Published online ahead of print August 1, 2016]. J Clin Oncol. doi:10.1200/JCO.2015.65.8013.