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Digital Breast Tomosynthesis Effectiveness

Comparison with digital mammography

Digital breast tomosynthesis (DBT) screening outcomes are sustainable over time, with significant recall reduction, increasing cancer cases per recalled patients, along with a decline in interval cancers. This according to an outcome analysis over a 4-year period of breast cancer screening where 44,468 examinations attributable to 23,958 unique women were analyzed. Researchers found:

• Recall rates rose slightly for years 1 to 3 of DBT (88, 90, and 92 per 1,000 screened, respectively) but remained significantly reduced compared with the digital mammography (DM) of 104 per 1,000 screened.

• Odds ratios were DM vs DBT1, 0.83; DM vs DBT2, 0.85; and DM vs DBT3, 0.87.

• Cancer cases per recalled patients continued to rise from DM0 rate of 4.4% to 6.2%, 6.5%, and 6.7% for years 1 to 3 of DBT, respectively.

• Outcomes assessed for the most recent screening for individual women undergoing only 1, 2 or 3 DBT screenings during the study period demonstrated decreasing recall rates of 130, 78, and 59 per 1,000 screened, respectively.

Citation: McDonald ES, Oustimov A, Weinstein SP, Synnestvedt MB, Schnall M, Conant EF. Effectiveness of digital breast tomosynthesis compared with digital mammography: Outcomes analysis from 3 years of breast cancer screening. [Published online ahead of print February 18, 2016]. JAMA Oncol. doi: 10.1001/jamaoncol.2015.5536.