Aromatase inhibitor (AI) users do not have an elevated risk of the most serious cardiovascular events (ie, cardiac ischemia or stroke) when compared with tamoxifen users, according to a retrospective cohort of 13,272 postmenopausal women with breast cancer diagnosed from January 1, 1991 to December 31, 2010 and followed up for 21 years. Women were grouped by endocrine therapy status (tamoxifen citrate only, AI only, both, or neither). Researchers found:
• During 72,886 person-years in 13,273 women (mean age, 66.8 years), 3,711 CVD events were observed.
• AI-only users had a similar risk of cardiac ischemic (aHR=0.97) and stroke (aHR=0.97) as tamoxifen-only users, in multivariable analyses.
• There was an increased risk of other CVD (dysrhythmia, valvular dysfunction, and pericarditis; aHR=1.29), in women who used AIs only or sequentially after tamoxifen (aHR=1.26) vs tamoxifen as well as nonhormone users (aHR=1.18).
Citation: Haque R, Shi J, Schottinger JE, et al. Cardiovascular disease after aromatase inhibitor use. [Published online ahead of print April 21, 2016]. JAMA Oncol. doi:10.1001/jamaoncol.2016.0429.
This Week's Must Reads
Must Reads in Breast Cancer
Gender Images & Social Expectations in BC Diagnosis, Cancer; ePub 2018 Sep 24; Kim, Glassgow, et al
Predicting Mammography Adherence by Income Level, Women’s Health Issues; ePub 2018 Aug 8; Gathirua-Mwangi, et al
Estrogen-alone Therapy & Invasive Breast Cancer, Menopause; ePub 2018 May 7; Shufelt, et al
Missed Breast Cancers in High Risk MRI Screening, Breast Cancer Res Treat; ePub 2018 Jan 31; Vreemann, et al