Clinical Edge

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Cigarette Smoking in Breast Cancer

Assessing effects before and after BC diagnosis

Smoking before or after diagnosis was associated with a higher mortality from breast cancer (BC) and several other causes, according to a study of 20,691 women, ages 20 to 79 years, diagnosed with incident localized or regional invasive BC, including a subset of 4,562 of these women who were recontacted a median 6 years after diagnosis. Researchers found:

• During a median 12 years, 6,778 women died, including 2,894 who died as a result of BC.

• Active smokers 1 year before BC diagnosis were more likely than never smokers to die of BC (HR=1.25), respiratory cancer (HR=14.48), other respiratory disease (HR=6.02), and cardiovascular disease (HR=2.08).

• The 10% of women who continued to smoke after diagnosis were more likely than never smokers to die of BC (HR=1.72).

• Those who quit smoking had lower mortality from BC (HR=0.67) and respiratory cancer (HR=0.39) vs those who continued to smoke.

Citation: Passarelli MN, Newcomb PA, Hampton JM, et al. Cigarette smoking before and after breast cancer diagnosis: Mortality from breast cancer and smoking-related diseases. [Published online ahead of print January 25, 2016]. J Clin Oncol. doi:10.1200/JCO.2015.63.9328.