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BC Screening Using Tomosynthesis with DM

Breast Cancer Res Treat; ePub 2016 Mar 1; Conant, et al

Implementation of digital breast tomosynthesis (DBT) screening increased cancer detection and reduced patient recall when compared to digital mammography (DM) alone. This according to a cohort study of data from 3 research centers performing DBT screening from 2011 to 2014 where recall and biopsy rates were assessed from 198,881 women aged 40 to 74 years undergoing screening (142,883 DM and 55,998 DBT examinations). Cancer, cancer detection, and false negative rates and positive predictive values were assessed on examination with 1 year follow-up. Researchers found:

• There was a reduction in recall with DBT compared to DM (8.7% vs 10.4%), with adjusted OR=0.68.

• DBT demonstrated a statistically significant increase in cancer detection vs DM (5.9 vs 4.4/1,000 screened, aOR=1.45), an improvement in PPV1 (6.4% vs 4.1%, aOR=2.02), and no significant difference in false negative rates for DBT vs DM (0.46 vs 0.60/1,000 screened).

Citation: Conant EF, Beaber EF, Sprague BL, et al. Breast cancer screening using tomosynthesis in combination with digital mammography compared to digital mammography alone: a cohort study within the PROSPR consortium. [Published online ahead of print March 1, 2016]. Breast Cancer Res Treat. doi:10.1007/s10549-016-3695-1.