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Active Psoriatic Arthritis, Ankylosing Spondylitis Linked to Increase in Adverse Pregnancy Outcomes

Key clinical point: Psoriatic arthritis and ankylosing spondylitis increased the risk of certain adverse pregnancy outcomes, although outcomes were generally favorable overall.

Major finding: Compared with healthier women, those with psoriatic arthritis had an 81% increased risk for moderate preterm delivery (32-36 weeks’ gestation), among other adverse obstetric outcomes, while women with ankylosing spondylitis had a 67% increased risk of infant hospitalization in the neonatal intensive care unit.

Study details: Analysis of 963 women in the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease Project.

Disclosures: The authors reported no conflicts of interest. The OTIS Collaborative Research Group has received research funding from AbbVie, Amgen, Bristol-Myers Squibb, Janssen, Pfizer, and others.


Smith CJF et al. Arthritis Care Res. 2019 May 10. doi: 10.1002/acr.23924.