Ampicillin dosage questioned


In “Preventing group B strep” [April] by Teresa Marino, MD, and Curtis Cetrulo, MD, the dosage listed for ampicillin is “2 g intravenously every 4 hours.” However, the Centers for Disease Control (CDC) guidelines recommend 2 g initially, followed by 1 g every 4 hours. Is this an error on the authors’ part or a change in the recommendation?

In addition, we also have several physicians at our hospital who start prophylaxis treatment at 12 to 18 hours after ruptured membranes, even if the screening culture at 35 to 37 weeks’ gestation is negative. Isn’t this defeating the purpose of a screening culture?

Todd Meisinger, MD
Greensboro, NC

Dr. Marino responds:

This is the ampicillin dosage we prefer to use at our institution and not the dose recommended by the CDC, as correctly quoted by Dr. Meisinger.

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