Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Opioid Prescribing & Patient Use After Hysterectomy

Obstet Gynecol; ePub 2017 Nov 3; As-Sanie, et al

In the 2 weeks following hysterectomy, gynecologists prescribed twice the amount of opioids for postoperative pain than the average patient uses after a surgical procedure, a recent study found. The prospective quality initiative at a large academic medical center included 103 patients undergoing hysterectomy for benign, nonobstetric indications between August and December 2015. After hysterectomy, opioid use and pain scores (0-10 numeric rating scale) were collected. Primary outcomes were total opioids prescribed and consumed in the 2 weeks after hysterectomy. Secondary outcomes included daily opioid use and daily pain severity for 14 days after hysterectomy. Researchers found:

  • Median amount of opioid prescribed was 200 oral morphine equivalents.
  • Patients reported using ~half of the opioids prescribed.
  • Preoperative Fibromyalgia Survey Scores, overall body pain, preoperative opioid use, prior endometriosis, abdominal hysterectomy, and uterine weight were identified as significant predictors of opioid consumption.


As-Sanie S, Till SR, Mowers EL, et al. Opioid prescribing patterns, patient use, and postoperative pain after hysterectomy for benign indications. [Published online ahead of print November 3, 2017]. Obstet Gynecol. doi:10.1097/AOG.0000000000002344.

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