Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Stress & Fatigue During Menopausal Transition

Menopause; ePub 2017 Nov 20; Taylor-Swanson, et al

Coupling relationships of stress on fatigue show evidence for shifts in regulatory relationships with one another across the menopausal transition (MT), a recent study found. The study evaluated the regulatory dynamics between stress and fatigue experienced by women during the MT and early postmenopause (EPM). Participants were from the longitudinal Seattle Midlife Women’s Health Study with eligible women (n=56) completing questionnaires on ≥60 occasions. The total number of observations across the sample was 4,224. Women were staged in either late reproductive, early or late transition, or EPM stage. Researchers found:

  • Eligible women (median age 35 years) were well educated, employed, married or partnered, and white.
  • Fit indices suggested the model depicts the relationships of stress and fatigue.
  • A loss in model fit across stages suggests that the 4 stages differed in their dynamics.
  • All stages showed fixed-point attractor dynamics: fatigue became less stable over time, and stress generally became more stable over time.


Taylor-Swanson L, Wong AE, Pincus D, et al. The dynamics of stress and fatigue across menopause: Attractors, coupling, and resilience. [Published online ahead of print November 20, 2017]. Menopause. doi:10.1097/GME.0000000000001025.

This Week's Must Reads

Low Dose Aspirin and Spontaneous Preterm Birth, Am J Obstet Gynecol; ePub 2018 Jun 15; Andrikopoulou, et al

New Persistent Opioid Use After Hysterectomy, Am J Obstet Gynecol; ePub 2018 Jun 18; Swenson, et al

Salpingectomy at Time of Cesarean Delivery, Contraception; ePub 2018 Jun 20; Lehn, et al

Cardiac Autonomic Function in Midlife Women, Menopause; ePub 2018 Jun 18; Fu, et al

ACOG Recommendations for Maternal Immunization, Obstet Gynecol; ePub 2018 Jun; Ault, Riley, et al

Must Reads in Menopause

Cardiac Autonomic Function in Midlife Women, Menopause; ePub 2018 Jun 18; Fu, et al

Vasomotor Symptoms in Older Women, Menopause; ePub 2018 May 7; David, et al

Estrogen-alone Therapy & Invasive Breast Cancer, Menopause; ePub 2018 May 7; Shufelt, et al

Vascular Dysfunction During Menopausal Transition, Menopause; ePub 2018 Apr 9; Hildreth, et al

Menopausal HT & Hyperkyphosis Prevention , Menopause; ePub 2018 Feb 16; Woods, et al