Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Seizures and Periodic Discharges in Traumatic Brain Injury

Ann Neurol; ePub 2016 Feb 28; Vespa, Tubi, et al

In patients with traumatic brain injury (TBI), seizures and pseudoperiodic discharges (PDs) are one mechanism for metabolic crisis, according to a study of 34 patients with TBI. Researchers found:

• 61% of patients with TBI experienced seizures or PDs.

• 42.9% of these seizures noted only on intracortal depth EEG and, in some cases, lasting many hours.

• Metabolic crisis, as measured by elevated cerebral microdialysis lactate/pyruvate ratio, occurred during seizures or PDs but not during electrically nonepileptic epochs.

Citation: Vespa P, Tubi M, Claasen J, et al. Metabolic crisis occurs with seizures and periodic discharges after brain trauma. [Published online ahead of print February 28, 2016]. Ann Neurol. doi:10.1002/ana.24606.

This Week's Must Reads

MS Risk Factors Contribute to Onset Heterogeneity, Mult Scler Relat Disord; ePub 2018 Dec 3; Briggs, et al

Severe Fatigue in MS Predicts EDSS Worsening, Mult Scler; ePub 2018 Dec 3; Vaughn, et al

Cerebrospinal Fluid Biomarkers and MS Severity, Mult Scler Relat Disord; ePub 2018 Dec 5; Masvekar, et al

Research-to-Practice Gaps in Multiple Sclerosis, Int J MS Care; ePub 2018 Nov 27; Walker, et al

Head Trauma, Autoimmune Diseases: No Link with MS , Neuroepidemiol; ePub 2018 Nov 26; Abdollahpour, et al

Must Reads in Traumatic Brain Injury

Concussion and/or Mild TBI Linked with Suicide Risk, JAMA Neurology; ePub 2018 Nov 12; Fralick, et al

GFAP: Marker of Brain Injury in Acute Mild TBI , Neurology; ePub 2018 Sept 12; Gill, Latour, et al

Deployment-Related TBI and Back Pain in Veterans, J Pain; ePub 2018 Aug 30; Suri, Stolzmann, et al

Poor Sleep Linked to Slow Recovery from TBI, Sleep; ePub 2018 Jul 24; Kalmbach, Conroy, et al

Psychiatric Risk Factors for Recurrent Neurotrauma, Brain Inj; ePub 2018 Jun 18; Hayward, Fessler, et al