In a recent large, case-control study, hypocalcemia and hypomagnesemia at diagnosis were significantly associated with ruptured aneurysms. Furthermore, impaired hemostasis caused by hypocalcemia and hypomagnesemia may explain this association. The medical records of 4,701 patients, including 1,201 prospective patients, diagnosed at the Brigham and Women’s Hospital and Massachusetts General Hospital between 1990 and 2016 were reviewed and analyzed. 1,277 patients had available serum calcium, magnesium, and albumin values within 1 day of diagnosis. Individuals were divided into cases with ruptured aneurysms and controls with unruptured aneurysms. Univariable and multivariable logistic regression analyses were performed to determine the association between serum albumin-corrected total calcium and magnesium levels and ruptured aneurysms. Researchers found that in multivariable analysis, both albumin-corrected calcium (odds ratio, 0.33) and magnesium (odds ratio, 0.40) were significantly and inversely associated with ruptured intracranial aneurysms.
Can A, Rudy RF, Castro VM, et al. Low serum calcium and magnesium levels and rupture of intracranial aneurysms. [Published online ahead of print May 29, 2018]. Stroke. doi:10.1161/STROKEAHA.118.020963.
This Week's Must Reads
Social Cognitive Theory and Physical Activity in MS, Int J MS Care; 2018 May/June; Uszynski, Casey, et al
Wheeled Mobility Device Intervention Found Feasible, Int J MS Care; 2018 May/June; Rice, Isaacs, et al
Somatic Symptoms of Depression/Anxiety in MS, Int J MS Care; 2018 May/June; Jones, Salem, et al
Turning: Important Marker of Gait and Balance in MS, PLoS One; ePub 2018 Jun 7; Adusumilli, Lancia, et al
Autonomic Dysfunction Compared in Patients with MS, Clin Neurophysiol; 2018 Aug; Adamec, Crnošija, et al
Must Reads in Stroke
PFO Closure Linked with Reduced Recurrent Stroke , J Stroke Cerebrovasc Dis; ePub 2018 May 24; Garg, et al
Low Calcium, Magnesium Levels and Aneurysm Rupture, Stroke; ePub 2018 May 29; Can, Rudy, Castro, et al
Sickle Cell Trait, Ischemic Stroke Link Examined, JAMA Neurology; ePub 2018 Apr 23; Hyacinth, et al
Proximity to Major Roadway, Stroke Risk Linked, Stroke; ePub 2018 Mar 14; Kulick, et al
ED Transfers for IS/TIA More than Doubled, 2006-14, Neurology; ePub 2018 Apr 4; George, Doyle, et al