Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Low Calcium, Magnesium Levels and Aneurysm Rupture

Stroke; ePub 2018 May 29; Can, Rudy, Castro, et al

In a recent large, case-control study, hypocalcemia and hypomagnesemia at diagnosis were significantly associated with ruptured aneurysms. Furthermore, impaired hemostasis caused by hypocalcemia and hypomagnesemia may explain this association. The medical records of 4,701 patients, including 1,201 prospective patients, diagnosed at the Brigham and Women’s Hospital and Massachusetts General Hospital between 1990 and 2016 were reviewed and analyzed. 1,277 patients had available serum calcium, magnesium, and albumin values within 1 day of diagnosis. Individuals were divided into cases with ruptured aneurysms and controls with unruptured aneurysms. Univariable and multivariable logistic regression analyses were performed to determine the association between serum albumin-corrected total calcium and magnesium levels and ruptured aneurysms. Researchers found that in multivariable analysis, both albumin-corrected calcium (odds ratio, 0.33) and magnesium (odds ratio, 0.40) were significantly and inversely associated with ruptured intracranial aneurysms.


Can A, Rudy RF, Castro VM, et al. Low serum calcium and magnesium levels and rupture of intracranial aneurysms. [Published online ahead of print May 29, 2018]. Stroke. doi:10.1161/STROKEAHA.118.020963.

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