Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

BP Variability Leads to Worse Outcome After Stroke

Stroke; ePub 2018 Jul 16; de Havenon, Majersik, et al

In a secondary analysis of ATACH-2 (Antihypertensive Treatment of Acute Cerebral Hemorrhage II) trial, researchers demonstrate that increased systolic blood pressure variability (BPV) is associated with worse long-term neurological outcome following acute ischemic stroke. The primary outcome of this study was a 3-month follow-up modified Rankin Scale of 3 to 6, and the secondary outcome was a utility-weighted modified Rankin Scale. Researchers calculated blood pressure mean and variability using systolic blood pressure from the acute period (2-24 hours post-randomization) and subacute period (days 2, 3, and 7). The acute period included 913 patients and the subacute included 877. They found:

  • For 5 different statistical measures of systolic BPV, there was a consistent association between increased BPV and worse neurological outcome in both the acute and subacute periods.
  • This association was not found for systolic blood pressure mean.

Citation:

de Havenon A, Majersik JJ, Stoddard G, et al. Increased blood pressure variability contributes to worse outcome after intracerebral hemorrhage. An analysis of ATACH-2. [Published online ahead of print July 16, 2018]. doi:10.1161/STROKEAHA.118.022133.

This Week's Must Reads

Body Image Dissatisfaction in Patients with MS, Int J MS Care; ePub 2018 Nov 1; Stevens, et al

Unemployment Linked with Stigma in MS, Int J MS Care; ePub 2018 Nov 1; Hategeka, et al

Total Hip, Knee Arthroplasty in Patients with MS, Int J MS Care; 2018 Sep-Oct; Gutman, et al

Intracerebral Hemorrhage in Multiple Sclerosis, J Stroke Cerebrovasc Dis; ePub 2018 Oct 29; Zulfiger, et al

Assessment of CAT Version of Neuro-QOL for MS, Mult Scler; ePub 2018 Nov 1; Healy, et al

Must Reads in Stroke

Ischemic Stroke Transfers in the Northeastern US, J Stroke Cerebrovasc Dis; ePub 2018 Oct 30; Zachrison, et al

Predictors of Recurrent Hospitalizations Post-TIA, J Stroke Cerebrovasc Dis; ePub 2018 Oct 17; Yousufuddin, et al

Recurrent Stroke Risk Higher for Blacks than Whites, Neurology; ePub 2018 Oct 3; Albright, Huang, et al

Sleep Duration/Stroke Link Differs by Race and Sex, Neurology; ePub 2018 Oct 3; Petrov, Howard, et al

Intracerebral Hemorrhage Survivors’ Outcomes Studied, J Stroke Cerebrovasc Dis; ePub 2018 Sep 28; Griauzde, et al