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Walking Speed, Endurance Studied in Persons with MS

J Neurophysiol; ePub 2018 Jan 3; Almuklass, et al

Walking speed and endurance in persons with relapsing-remitting multiple sclerosis (RRMS) were reduced in individuals with longer interspike intervals (ISIs), weaker dorsiflexors, and worse plantar flexor force steadiness, according to a recent study that examined walking performance and disability status in individuals with self-reported walking disabilities due to MS. 23 individuals with RRMS (aged 56±7 years) participated. They completed 1-3 evaluation sessions that involved 2 walking tests (25-ft. walk and 6-min. walk), a manual dexterity test, health-related questionnaires, and measurement of strength, force steadiness, and motor unit discharge characteristics of lower leg muscles. Researchers found:

  • There were statistically significant differences between the 3 muscles in mean ISI and ISI distributions during steady submaximal contractions with the plantar flexor and dorsiflexor muscles.
  • The regression models explained 40% of the variance in the 6-min. walk distance and 47% of the variance in 25-ft. walk time with 2 or 3 variables that included mean ISI for 1 of the plantar flexor muscles, dorsiflexor strength, and force steadiness.
Citation:

Almuklass AM, Davis L, Hamilton LD, Vieira TM, Botter A, Enoka RM. Motor unit discharge characteristics and walking performance of individuals with multiple sclerosis. [Published online ahead of print January 3, 2018]. J Neurophysiol. doi:10.1152/jn.00598.2017.

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Must Reads in Multiple Sclerosis

Pediatric Onset MS Linked with Reduced Parental QOL, Mult Scler; ePub 2018 Aug 30; O’Mahony, et al

Depressive Symptoms Negatively Impact on MS, J Neuropsychiatry Clin Neurosci; ePub 2018 Sep 6; Gill, et al

Evaluation of the MULES Picture Naming Test, J Neurol Sci; ePub 2018 Aug 23; Seay, Akhand, et al

Postrelapse Rehabilitation Use in MS Examined , Int J MS Care; ePub 2018 Sep 5; Asano, Eitzen, et al

Thalamic White Matter in Patients with MS, Hum Brain Mapp; 2018 Oct; Bergsland, et al