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Pregnancy Rates for Women with MS Increasing

Neurology; ePub 2018 Sep 28; Houtchens, et al

Pregnancy rates in women with multiple sclerosis (MS) have been increasing, according to a recent study. In addition, high rates of claims for several peripartum complications were observed in women with and those without MS. In a retrospective US administrative claims study, researchers used data from January 1, 2006, to June 30, 2015. All data for women with MS were included. A nationally representative 5% random sample from approximately 58 million women without MS was used to compute the dataset. They found:

  • From 2006 to 2014, the adjusted proportion of women with MS and pregnancy increased from 7.91% to 9.47%; the adjusted proportion without MS and with pregnancy decreased from 8.83% to 7.75%.
  • The difference in linear trend (0.17% increase and 0.15% decrease in per-annum pregnancy rates) was significant (t statistic = 7.8).
  • After matching (n=2,115 per group), a higher proportion of women with MS than without had claims for premature labor, infection, cardiovascular disease, anemia/acquired coagulation disorders, neurologic complications, sexually transmitted diseases, acquired fetal damage, and congenital fetal malformations.
Citation:

Houtchens MK, Edwards NC, Schneider G, Stern K, Phillips AL. Pregnancy rates and outcomes in women with and without MS in the United States. [Published online ahead of print September 28, 2018]. Neurology. doi:10.1212/WNL.0000000000006384.

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Severe Fatigue in MS Predicts EDSS Worsening, Mult Scler; ePub 2018 Dec 3; Vaughn, et al

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