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Ocrelizumab Proves Efficacious in MS Treatment

Ann Pharmacother; ePub 2017 Dec 12; Stahnke, et al

Ocrelizumab, a new B-cell–targeted therapy for multiple sclerosis (MS), demonstrated efficacy in the treatment of relapsing and primary progressive MS (PPMS), according to a recent literature review, and is the first therapy approved for patients with PPMS. A comprehensive literature search was conducted using search terms “ocrelizumab” and “multiple sclerosis” using the date range of 1946 through October 2017. Investigators found:

  • A phase II trial established 600 mg intravenously every 6 months as the preferred dosing schedule.
  • 2 phase III trials evaluated the efficacy of ocrelizumab in patients with relapsing remitting MS, and individual and pooled analysis demonstrated a significant reduction in annualized relapse rate, disability progression at 12 weeks, and gadolinium-enhancing lesions on magnetic resonance imaging (MRI).
  • Patients with PPMS were evaluated in a third phase III trial, which showed a significant decrease in disease progression at 12 weeks and volume of T2-weighted lesions on MRI.
Citation:

Stahnke AM, Holt KM. Ocrelizumab: A new B-cell therapy for relapsing remitting and primary progressive multiple sclerosis. [Published online ahead of print December 12, 2017]. Ann Pharmacother. doi:10.1177/1060028017747635.

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Must Reads in Multiple Sclerosis

Identifying Priority Outcomes in DMT Selection, Neurol Clin Pract; ePub 2018 Apr 23; Day, et al

SRS Beneficial for MS-Related Trigeminal Neuralgia, Neurosurgery; ePub 2018 Apr 23; Xu, Mathieu, et al

TECA Assessment for MS Both Valid and Reliable, Mult Scler Relat Disord; ePub 2018 May 2; Charvet, et al

Calorie Restriction Beneficial to Patients with MS, Mult Scler Relat Disord; ePub 2018 May 5; Fitzgerald, et al

Novel Technique Boosts Diagnostic Specificity in MS, Am J Neuroradiol; ePub 2018 Apr 26; Tillema, et al