Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

MS, Crohn’s Share Similar Birth-Cohort Patterns

Mult Scler; 2018 Feb; Sonnenberg, Ajdacic-Gross

Birth-cohort patterns indicate that the development of Crohn’s disease and multiple sclerosis (MS) is influenced by exposure to environmental risk factors during an early period of life, according to a recent study. These environmental risk factors may be similar or even identical in Crohn’s disease and MS. Researchers analyzed mortality data of Crohn’s disease and MS from the US, Canada, England, Italy, the Netherlands, and Switzerland during the past 60 years. Age–period–cohort (APC) analyses based on logit models served to disentangle the separate influences of age, period, and cohort effects on the overall time trends. They found:

  • The long-term time trends of Crohn’s disease and MS have been shaped by strikingly similar birth-cohort patterns.
  • In both diseases alike, mortality increased in all generations born prior to 1910.
  • It peaked among generations born between 1910 and 1930 and then declined in all subsequent generations.
  • Similar birth-cohort patterns of Crohn’s disease and MS were found in each country analyzed separately.
Citation:

Sonnenberg A, Ajdacic-Gross V. Similar birth-cohort patterns in Crohn’s disease and multiple sclerosis. Mult Scler. 2018;24(2):140-149. doi:10.1177/1352458517691620.

This Week's Must Reads

Behavioral Activation May Cut Dementia Disparity, JAMA Neurology; ePub 2018 Sep 10; Rovner, et al

GFAP: Marker of Brain Injury in Acute Mild TBI , Neurology; ePub 2018 Sept 12; Gill, Latour, et al

Study Identifies Acute Ischemic Stroke Risk Factors, J Stroke Cerebrovasc Dis; ePub 2018 Sep 8; Kim, et al

Deployment-Related TBI and Back Pain in Veterans, J Pain; ePub 2018 Aug 30; Suri, Stolzmann, et al

Treatment Outcomes Post-Surgery for Moyamoya Disease, J Neurol; ePub 2018 Sep 8; Kahn, Kaur, Stein, et al

Must Reads in Multiple Sclerosis

Pediatric Onset MS Linked with Reduced Parental QOL, Mult Scler; ePub 2018 Aug 30; O’Mahony, et al

Depressive Symptoms Negatively Impact on MS, J Neuropsychiatry Clin Neurosci; ePub 2018 Sep 6; Gill, et al

Evaluation of the MULES Picture Naming Test, J Neurol Sci; ePub 2018 Aug 23; Seay, Akhand, et al

Postrelapse Rehabilitation Use in MS Examined , Int J MS Care; ePub 2018 Sep 5; Asano, Eitzen, et al

Thalamic White Matter in Patients with MS, Hum Brain Mapp; 2018 Oct; Bergsland, et al