Birth-cohort patterns indicate that the development of Crohn’s disease and multiple sclerosis (MS) is influenced by exposure to environmental risk factors during an early period of life, according to a recent study. These environmental risk factors may be similar or even identical in Crohn’s disease and MS. Researchers analyzed mortality data of Crohn’s disease and MS from the US, Canada, England, Italy, the Netherlands, and Switzerland during the past 60 years. Age–period–cohort (APC) analyses based on logit models served to disentangle the separate influences of age, period, and cohort effects on the overall time trends. They found:
- The long-term time trends of Crohn’s disease and MS have been shaped by strikingly similar birth-cohort patterns.
- In both diseases alike, mortality increased in all generations born prior to 1910.
- It peaked among generations born between 1910 and 1930 and then declined in all subsequent generations.
- Similar birth-cohort patterns of Crohn’s disease and MS were found in each country analyzed separately.
Sonnenberg A, Ajdacic-Gross V. Similar birth-cohort patterns in Crohn’s disease and multiple sclerosis. Mult Scler. 2018;24(2):140-149. doi:10.1177/1352458517691620.
This Week's Must Reads
Vascular Risk Linked with Cognitive Decline, JAMA Neurology; ePub 2018 May 21; Rabin, et al
Guillain-Barré, Zika Virus, and Morbidity, JAMA Neurology; ePub 2018 May 21; Dirlikov, et al
PFO Closure Linked with Reduced Recurrent Stroke , J Stroke Cerebrovasc Dis; ePub 2018 May 24; Garg, et al
Integrated MRI and [11C]‐PBR28 PET Imaging in ALS, Ann Neurol; ePub 2018 May 8; Alshikho, et al
Low Calcium, Magnesium Levels and Aneurysm Rupture, Stroke; ePub 2018 May 29; Can, Rudy, Castro, et al
Must Reads in Multiple Sclerosis
UVB Not Significantly Linked with Age of MS Onset, Mult Scler Relat Disord; 2018 Apr; Amram, et al
White Matter and Reduced Conscientiousness in MS, Hum Brain Mapp; ePub 2018 May 8; Fuchs, et al
Functional Connectivity, Walking Performance in MS, Neuropsychologia; 2018 Aug; Bollaert, Poe, et al
MS Lesions Effect on Spinal Cord Connectivity, Brain; 2018 Jun; Conrad, Barry, Rogers, et al
Preferential Spinal Cord Volume Loss in PPMS, Mult Scler; ePub 2018 May 21; Tsagkas, et al