Hypertension and heart disease contribute to advanced brain atrophy in multiple sclerosis (MS) patients, according to a recent study. Cardiovascular diseases (CVDs), however, did not contribute to additional lesion accrual, although CVD comorbidities in MS patients may contribute to neurodegenerative tissue injury that can be detected with brain MRI. 194 MS patients and 43 controls without neurologic disease were followed for 5‐years. Full physical and neurological evaluations, plus structured questionnaire responses investigating CVD and risk factors, were collected. Lesion and brain atrophy outcomes were assessed with 3T MRI. Researchers found:
- Patients with diagnosis of heart disease showed higher white matter and whole brain volume loss compared to those without (‐4.2% vs ‐0.7% and ‐3.4% vs ‐1.6%, respectively).
- The percentage lateral ventricle volume change in MS patients with hypertension was higher compared to non‐hypertensive patients (24.5% vs 14.1%).
- Hyperlipidemia, smoking, and obesity/overweight were not associated with progression of MRI‐derived outcomes.
- CVDs did not contribute to larger lesion volume accrual over the 5‐year period.
- The presence of CVDs was not associated with MRI‐derived changes in the controls.
Jakimovski D, Gandhi S, Paunkoski I, et al. Hypertension and heart disease are associated with development of brain atrophy in multiple sclerosis: A 5‐year longitudinal study. [Published online ahead of print August 13, 2018]. Eur J Neurol. doi:10.1111/ene.13769.
This Week's Must Reads
Behavioral Activation May Cut Dementia Disparity, JAMA Neurology; ePub 2018 Sep 10; Rovner, et al
GFAP: Marker of Brain Injury in Acute Mild TBI , Neurology; ePub 2018 Sept 12; Gill, Latour, et al
Study Identifies Acute Ischemic Stroke Risk Factors, J Stroke Cerebrovasc Dis; ePub 2018 Sep 8; Kim, et al
Deployment-Related TBI and Back Pain in Veterans, J Pain; ePub 2018 Aug 30; Suri, Stolzmann, et al
Treatment Outcomes Post-Surgery for Moyamoya Disease, J Neurol; ePub 2018 Sep 8; Kahn, Kaur, Stein, et al
Must Reads in Multiple Sclerosis
Pediatric Onset MS Linked with Reduced Parental QOL, Mult Scler; ePub 2018 Aug 30; O’Mahony, et al
Depressive Symptoms Negatively Impact on MS, J Neuropsychiatry Clin Neurosci; ePub 2018 Sep 6; Gill, et al
Evaluation of the MULES Picture Naming Test, J Neurol Sci; ePub 2018 Aug 23; Seay, Akhand, et al
Postrelapse Rehabilitation Use in MS Examined , Int J MS Care; ePub 2018 Sep 5; Asano, Eitzen, et al
Thalamic White Matter in Patients with MS, Hum Brain Mapp; 2018 Oct; Bergsland, et al