Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Fear of Falling Impacts Leisure-Time Activity in MS

Gait Posture; ePub 2018 Jun 30; Kalron, Aloni, et al

A recent study highlights the impact of concern of falling, not falls, on physical activity in people with multiple sclerosis (PwMS). The sample included 190 PwMS (107 women), mean age 40.8 (SD=13.1), and mean disease duration of 6.4 (SD=8.3) years since diagnosis. Outcome measures included the Godin Leisure-Time Exercise Questionnaire (GLTEQ), Four Square Step Test (FSST), 2-Minute Walk test (2 mWT), Timed Up and Go test (TUG), Timed 25-Foot Walk test (T25FW), fall status, Falls Efficacy Scale International (FES-I), Modified Fatigue Impact Scale (MFIS), walking speed, and the Multiple Sclerosis Walking Scale self-reported questionnaire (MSWS-12). Researchers found:

  • 86 PwMS were classified as active (GLTEQ=31.6 [SD=16.7]); 104 were insufficiently active (GLTEQ=3.0 [SD=4.3].)
  • Insufficiently active PwMS demonstrated a slower walking speed, elevated fatigue, more concerns of falling, and additional walking difficulties compared to active PwMS.
  • Non-significant differences between groups were observed in the TUG, 2 mWT, FSST, T25FWT, and fall status.
  • According to the linear regression, by utilizing the FES-I, a 12.2% variance related to leisure-time physical activity was observed.
  • The independent variables—EDSS, MSWS-12, fatigue, and walking speed—were non-significant.


Kalron A, Aloni R, Givon U, Menascu S. Fear of falling, not falls, impacts leisure-time physical activity in people with multiple sclerosis. [Published online ahead of print June 30, 2018]. Gait Posture. doi:10.1016/j.gaitpost.2018.06.174.

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