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Depressive Symptoms Negatively Impact on MS

J Neuropsychiatry Clin Neurosci; ePub 2018 Sep 6; Gill, et al

Depressive symptoms have a significant negative impact on functional outcomes among people with multiple sclerosis (MS), relative to anxiety symptoms, a recent study found. Researchers aimed to examine the differential impact of depression and anxiety, measured by the Anxiety and Depression subscales of the Hospital Anxiety and Depression Scale (HADS-A and HADS-D), on functional outcomes among people with MS. Using a retrospective chart review of 128 people with MS, they used exploratory structural equation modeling to examine the relation of HADS-A and HADS-D to functional outcomes, namely employment status, fatigue (with the Fatigue Severity Scale), disability (with the Expanded Disability Status Scale [EDSS]), and cognition (with the Symbol Digit Modalities Test [SDMT]). They found:

  • After the authors controlled for the effects of covariates, HADS-A was negatively associated with EDSS (β=–0.22) and positively associated with vocation (β=0.23).
  • In contrast, HADS-D was positively correlated with fatigue (β=0.37) and EDSS (β=0.26) and negatively correlated with vocation (β=–0.32) and SDMT (β=–0.28).
  • HADS-A and HADS-D explained 5% of the variability in employment, 14.5% in fatigue, 1.6% in EDSS, and 4.3% in SDMT, beyond the effects of the covariates.

Citation:

Gill S, Santo J, Blair M, Morrow SA. Depressive symptoms are associated with more negative functional outcomes than anxiety symptoms in persons with multiple sclerosis. [Published online ahead of print September 6, 2018]. J Neuropsychiatry Clin Neurosci. doi:10.1176/appi.neuropsych.18010011.

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Must Reads in Multiple Sclerosis

MS Risk Factors Contribute to Onset Heterogeneity, Mult Scler Relat Disord; ePub 2018 Dec 3; Briggs, et al

Severe Fatigue in MS Predicts EDSS Worsening, Mult Scler; ePub 2018 Dec 3; Vaughn, et al

Cerebrospinal Fluid Biomarkers and MS Severity, Mult Scler Relat Disord; ePub 2018 Dec 5; Masvekar, et al

Research-to-Practice Gaps in Multiple Sclerosis, Int J MS Care; ePub 2018 Nov 27; Walker, et al

Head Trauma, Autoimmune Diseases: No Link with MS , Neuroepidemiol; ePub 2018 Nov 26; Abdollahpour, et al