Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cognitive Fatigue Examined in Patients with MS

Mult Scler; 2018 Feb; Golan, Doniger, et al

Cognitive fatigue in patients with multiple sclerosis (PwMS) is not independently related to objective cognitive impairment, according to a recent study. Depression may influence cognitive function of PwMS, primarily when it is severe. Therefore, cognitive impairment in PwMS should not be ascribed to fatigue or mild depression. PwMS (n=699) completed a computerized cognitive testing battery with age- and education-adjusted cognitive domain scores. Disability (Expanded Disability Status Scale [EDSS]), cognitive fatigue, and depression were concurrently evaluated. Researchers found:

  • Both cognitive fatigue and depression were significantly and negatively correlated with the same cognitive domains: information processing speed, executive function, attention, motor function, and memory.
  • Multivariate analysis revealed significant, but small, independent correlations only between depression and neuropsychological test results, while cognitive fatigue had no independent correlation with objective cognitive function except for a trend toward impaired motor function in highly-fatigued PwMS.
  • Depression and cognitive fatigue accounted for no more than 6% of the variance in objective cognitive domain scores.

Citation:

Golan D, Doniger GM, Wissemann K, et al. The impact of subjective cognitive fatigue and depression on cognitive function in patients with multiple sclerosis. Mult Scler. 2018;24(2):196-204. doi:10.1177/1352458517695470.

This Week's Must Reads

Behavioral Activation May Cut Dementia Disparity, JAMA Neurology; ePub 2018 Sep 10; Rovner, et al

GFAP: Marker of Brain Injury in Acute Mild TBI , Neurology; ePub 2018 Sept 12; Gill, Latour, et al

Study Identifies Acute Ischemic Stroke Risk Factors, J Stroke Cerebrovasc Dis; ePub 2018 Sep 8; Kim, et al

Deployment-Related TBI and Back Pain in Veterans, J Pain; ePub 2018 Aug 30; Suri, Stolzmann, et al

Treatment Outcomes Post-Surgery for Moyamoya Disease, J Neurol; ePub 2018 Sep 8; Kahn, Kaur, Stein, et al

Must Reads in Multiple Sclerosis

Pediatric Onset MS Linked with Reduced Parental QOL, Mult Scler; ePub 2018 Aug 30; O’Mahony, et al

Depressive Symptoms Negatively Impact on MS, J Neuropsychiatry Clin Neurosci; ePub 2018 Sep 6; Gill, et al

Evaluation of the MULES Picture Naming Test, J Neurol Sci; ePub 2018 Aug 23; Seay, Akhand, et al

Postrelapse Rehabilitation Use in MS Examined , Int J MS Care; ePub 2018 Sep 5; Asano, Eitzen, et al

Thalamic White Matter in Patients with MS, Hum Brain Mapp; 2018 Oct; Bergsland, et al