Before using brain volume loss (BVL) as a marker of therapeutic response in multiple sclerosis (MS), certain biological and methodological issues must be clarified. This according to a recent study that assessed the dynamics of BVL as MS progresses and evaluated the repeatability and exchangeability of BVL estimates. A cohort of patients (n=140) who had either clinically isolated syndrome or MS underwent a series of annual MRI scans. Images from 2 cohorts of healthy volunteers were used to evaluate short-term repeatability of the MRI measurements (n=34) and annual BVL (n=20). Researchers found:
- The BVL rates were higher in the first 5 years after MS onset with a direct association with steroids and an inverse association with age at MS onset, particularly in the first 5 years.
- Considering an expected loss of 0.5% to 1.35% per year, the poor repeatability of 2 separate imaging methods prevents their use at the individual level; also, volumetric estimates and the accuracy of thresholds to discriminate patients with MS from healthy volunteers differ in the 2 approaches.
Andorra M, Nakamura K, Lampert EJ, et al. Assessing biological and methodological aspects of brain volume loss in multiple sclerosis. [Published online ahead of print July 2, 2018]. JAMA Neurology. doi:10.1001/jamaneurol.2018.1596.
This Week's Must Reads
Readmission Rates After Thrombectomy for Stroke , J Stroke Cerebrovasc Dis; ePub 2018 Jul 3; Ramchand, et al
Admissions for Psychotic Episodes, Epilepsy Linked , Epilepsia; ePub 2018 Jul 4; Rossi, Kim, et al
Gender and Cognition in Overweight Adults with T2D, Alzheimers Dement; ePub 2018 Jul 4; Espeland, et al
Subjective Improvements in Sleep Apnea Examined, Sleep Med; ePub 2018 Jul 4; Bhat, Gupta, et al
FDA Approves Xeomin for Excessive Drooling, Merz North America news release; 2018 Jul 3
Must Reads in Multiple Sclerosis
Brain Volume Loss as Therapeutic Response Marker , JAMA Neurology; ePub 2018 Jul 2; Andorra, et al
Assessing Environmental Factors and Risk of MS, Mult Scler Relat Disord; ePub 2018 Jun 23; Mowry, et al
Fear of Falling Impacts Leisure-Time Activity in MS, Gait Posture; ePub 2018 Jun 30; Kalron, Aloni, et al
Identifying Anxiety Symptoms in Multiple Sclerosis, Arch Phys Med Rehab; ePub 2018 Jun 30; Hughes, et al
Spinal Cord Volume Loss: Marker of MS Progression, Neurology; ePub 2018 Jun 27; Tsagkas, Magon, et al