Although not statistically significant, there was a suggestive association of pesticide exposure with having multiple sclerosis (MS) among men, but only in those who were positive for HLA-DRB1*15:01, the strongest genetic variant associated with MS, according to a recent study. This study demonstrates the application of least absolute shrinkage and selection operator (LASSO), a regression analysis method that was used to identify a subset of exposures with potential relevance to disease in a large population-based (Kaiser Permanente Northern California [KPNC]) case-control study. Researchers found:
- There was a suggestive association of pesticide exposure with having MS among men, but only in those who were positive for HLA-DRB1*15:01 (odds ratio pooled =3.11).
- While this finding requires confirmation, it is interesting given the association between pesticide exposure and other neurological diseases.
Mowry EM, Hedström AK, Gianfrancesco MA, et al. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. [Published online ahead of print June 23, 2018]. Mult Scler Relat Disord. doi:10.1016/j.msard.2018.06.009.
This Week's Must Reads
Recurrent Stroke Risk Higher for Blacks than Whites, Neurology; ePub 2018 Oct 3; Albright, Huang, et al
Sleep Duration/Stroke Link Differs by Race and Sex, Neurology; ePub 2018 Oct 3; Petrov, Howard, et al
Intracerebral Hemorrhage Survivors’ Outcomes Studied, J Stroke Cerebrovasc Dis; ePub 2018 Sep 28; Griauzde, et al
Probable OSA Common in Refractory Epilepsy, Epilepsia; ePub 2018 Sep 24; McCarter, et al
FDA Approves Tiglutik for Treatment of ALS, ITF Pharma news release; 2018 Sep 6
Must Reads in Multiple Sclerosis
Anxiety/Cognition Association in Multiple Sclerosis, Int J MS Care; ePub 2018 Sep 27; Vissicchio, et al
Persons with MS and Anonymity on Social Media, Mult Scler Relat Disord; ePub 2018 Sep 19; Eijkholt
Pregnancy Rates for Women with MS Increasing, Neurology; ePub 2018 Sep 28; Houtchens, et al
Nature of Instability in Persons with MS Examined, Arch Phys Med Rehab; 2018 Oct; Peebles, et al
Stressful Life Events and Multiple Sclerosis, Mult Scler Relat Disord; ePub 2018 Sep 22; Abdollahpour, et al