Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Assessing Environmental Factors and Risk of MS

Mult Scler Relat Disord; ePub 2018 Jun 23; Mowry, et al

Although not statistically significant, there was a suggestive association of pesticide exposure with having multiple sclerosis (MS) among men, but only in those who were positive for HLA-DRB1*15:01, the strongest genetic variant associated with MS, according to a recent study. This study demonstrates the application of least absolute shrinkage and selection operator (LASSO), a regression analysis method that was used to identify a subset of exposures with potential relevance to disease in a large population-based (Kaiser Permanente Northern California [KPNC]) case-control study. Researchers found:

  • There was a suggestive association of pesticide exposure with having MS among men, but only in those who were positive for HLA-DRB1*15:01 (odds ratio pooled =3.11).
  • While this finding requires confirmation, it is interesting given the association between pesticide exposure and other neurological diseases.


Mowry EM, Hedström AK, Gianfrancesco MA, et al. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. [Published online ahead of print June 23, 2018]. Mult Scler Relat Disord. doi:10.1016/j.msard.2018.06.009.

This Week's Must Reads

Behavioral Activation May Cut Dementia Disparity, JAMA Neurology; ePub 2018 Sep 10; Rovner, et al

GFAP: Marker of Brain Injury in Acute Mild TBI , Neurology; ePub 2018 Sept 12; Gill, Latour, et al

Study Identifies Acute Ischemic Stroke Risk Factors, J Stroke Cerebrovasc Dis; ePub 2018 Sep 8; Kim, et al

Deployment-Related TBI and Back Pain in Veterans, J Pain; ePub 2018 Aug 30; Suri, Stolzmann, et al

Treatment Outcomes Post-Surgery for Moyamoya Disease, J Neurol; ePub 2018 Sep 8; Kahn, Kaur, Stein, et al

Must Reads in Multiple Sclerosis

Pediatric Onset MS Linked with Reduced Parental QOL, Mult Scler; ePub 2018 Aug 30; O’Mahony, et al

Depressive Symptoms Negatively Impact on MS, J Neuropsychiatry Clin Neurosci; ePub 2018 Sep 6; Gill, et al

Evaluation of the MULES Picture Naming Test, J Neurol Sci; ePub 2018 Aug 23; Seay, Akhand, et al

Postrelapse Rehabilitation Use in MS Examined , Int J MS Care; ePub 2018 Sep 5; Asano, Eitzen, et al

Thalamic White Matter in Patients with MS, Hum Brain Mapp; 2018 Oct; Bergsland, et al