Although not statistically significant, there was a suggestive association of pesticide exposure with having multiple sclerosis (MS) among men, but only in those who were positive for HLA-DRB1*15:01, the strongest genetic variant associated with MS, according to a recent study. This study demonstrates the application of least absolute shrinkage and selection operator (LASSO), a regression analysis method that was used to identify a subset of exposures with potential relevance to disease in a large population-based (Kaiser Permanente Northern California [KPNC]) case-control study. Researchers found:
- There was a suggestive association of pesticide exposure with having MS among men, but only in those who were positive for HLA-DRB1*15:01 (odds ratio pooled =3.11).
- While this finding requires confirmation, it is interesting given the association between pesticide exposure and other neurological diseases.
Mowry EM, Hedström AK, Gianfrancesco MA, et al. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. [Published online ahead of print June 23, 2018]. Mult Scler Relat Disord. doi:10.1016/j.msard.2018.06.009.
This Week's Must Reads
Readmission Rates After Thrombectomy for Stroke , J Stroke Cerebrovasc Dis; ePub 2018 Jul 3; Ramchand, et al
Admissions for Psychotic Episodes, Epilepsy Linked , Epilepsia; ePub 2018 Jul 4; Rossi, Kim, et al
Gender and Cognition in Overweight Adults with T2D, Alzheimers Dement; ePub 2018 Jul 4; Espeland, et al
Subjective Improvements in Sleep Apnea Examined, Sleep Med; ePub 2018 Jul 4; Bhat, Gupta, et al
FDA Approves Xeomin for Excessive Drooling, Merz North America news release; 2018 Jul 3
Must Reads in Multiple Sclerosis
Brain Volume Loss as Therapeutic Response Marker , JAMA Neurology; ePub 2018 Jul 2; Andorra, et al
Assessing Environmental Factors and Risk of MS, Mult Scler Relat Disord; ePub 2018 Jun 23; Mowry, et al
Fear of Falling Impacts Leisure-Time Activity in MS, Gait Posture; ePub 2018 Jun 30; Kalron, Aloni, et al
Identifying Anxiety Symptoms in Multiple Sclerosis, Arch Phys Med Rehab; ePub 2018 Jun 30; Hughes, et al
Spinal Cord Volume Loss: Marker of MS Progression, Neurology; ePub 2018 Jun 27; Tsagkas, Magon, et al