Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Assessing Environmental Factors and Risk of MS

Mult Scler Relat Disord; ePub 2018 Jun 23; Mowry, et al

Although not statistically significant, there was a suggestive association of pesticide exposure with having multiple sclerosis (MS) among men, but only in those who were positive for HLA-DRB1*15:01, the strongest genetic variant associated with MS, according to a recent study. This study demonstrates the application of least absolute shrinkage and selection operator (LASSO), a regression analysis method that was used to identify a subset of exposures with potential relevance to disease in a large population-based (Kaiser Permanente Northern California [KPNC]) case-control study. Researchers found:

  • There was a suggestive association of pesticide exposure with having MS among men, but only in those who were positive for HLA-DRB1*15:01 (odds ratio pooled =3.11).
  • While this finding requires confirmation, it is interesting given the association between pesticide exposure and other neurological diseases.

Citation:

Mowry EM, Hedström AK, Gianfrancesco MA, et al. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. [Published online ahead of print June 23, 2018]. Mult Scler Relat Disord. doi:10.1016/j.msard.2018.06.009.

This Week's Must Reads

Behavioral Activation May Cut Dementia Disparity, JAMA Neurology; ePub 2018 Sep 10; Rovner, et al

GFAP: Marker of Brain Injury in Acute Mild TBI , Neurology; ePub 2018 Sept 12; Gill, Latour, et al

Study Identifies Acute Ischemic Stroke Risk Factors, J Stroke Cerebrovasc Dis; ePub 2018 Sep 8; Kim, et al

Deployment-Related TBI and Back Pain in Veterans, J Pain; ePub 2018 Aug 30; Suri, Stolzmann, et al

Treatment Outcomes Post-Surgery for Moyamoya Disease, J Neurol; ePub 2018 Sep 8; Kahn, Kaur, Stein, et al

Must Reads in Multiple Sclerosis

Pediatric Onset MS Linked with Reduced Parental QOL, Mult Scler; ePub 2018 Aug 30; O’Mahony, et al

Depressive Symptoms Negatively Impact on MS, J Neuropsychiatry Clin Neurosci; ePub 2018 Sep 6; Gill, et al

Evaluation of the MULES Picture Naming Test, J Neurol Sci; ePub 2018 Aug 23; Seay, Akhand, et al

Postrelapse Rehabilitation Use in MS Examined , Int J MS Care; ePub 2018 Sep 5; Asano, Eitzen, et al

Thalamic White Matter in Patients with MS, Hum Brain Mapp; 2018 Oct; Bergsland, et al