Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Assessing Environmental Factors and Risk of MS

Mult Scler Relat Disord; ePub 2018 Jun 23; Mowry, et al

Although not statistically significant, there was a suggestive association of pesticide exposure with having multiple sclerosis (MS) among men, but only in those who were positive for HLA-DRB1*15:01, the strongest genetic variant associated with MS, according to a recent study. This study demonstrates the application of least absolute shrinkage and selection operator (LASSO), a regression analysis method that was used to identify a subset of exposures with potential relevance to disease in a large population-based (Kaiser Permanente Northern California [KPNC]) case-control study. Researchers found:

  • There was a suggestive association of pesticide exposure with having MS among men, but only in those who were positive for HLA-DRB1*15:01 (odds ratio pooled =3.11).
  • While this finding requires confirmation, it is interesting given the association between pesticide exposure and other neurological diseases.

Citation:

Mowry EM, Hedström AK, Gianfrancesco MA, et al. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. [Published online ahead of print June 23, 2018]. Mult Scler Relat Disord. doi:10.1016/j.msard.2018.06.009.

This Week's Must Reads

Readmission Rates After Thrombectomy for Stroke , J Stroke Cerebrovasc Dis; ePub 2018 Jul 3; Ramchand, et al

Admissions for Psychotic Episodes, Epilepsy Linked , Epilepsia; ePub 2018 Jul 4; Rossi, Kim, et al

Gender and Cognition in Overweight Adults with T2D, Alzheimers Dement; ePub 2018 Jul 4; Espeland, et al

Subjective Improvements in Sleep Apnea Examined, Sleep Med; ePub 2018 Jul 4; Bhat, Gupta, et al

FDA Approves Xeomin for Excessive Drooling, Merz North America news release; 2018 Jul 3

Must Reads in Multiple Sclerosis

Brain Volume Loss as Therapeutic Response Marker , JAMA Neurology; ePub 2018 Jul 2; Andorra, et al

Assessing Environmental Factors and Risk of MS, Mult Scler Relat Disord; ePub 2018 Jun 23; Mowry, et al

Fear of Falling Impacts Leisure-Time Activity in MS, Gait Posture; ePub 2018 Jun 30; Kalron, Aloni, et al

Identifying Anxiety Symptoms in Multiple Sclerosis, Arch Phys Med Rehab; ePub 2018 Jun 30; Hughes, et al

Spinal Cord Volume Loss: Marker of MS Progression, Neurology; ePub 2018 Jun 27; Tsagkas, Magon, et al