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Sickle Cell Trait, Ischemic Stroke Link Examined

JAMA Neurology; ePub 2018 Apr 23; Hyacinth, et al

Sickle cell trait (SCT) may not be associated with incidence of ischemic stroke among African American, according to a recent meta-analysis that suggests performing a more thorough clinical evaluation of a stroke patient with SCT rather than assuming that SCT is the etiologic factor for the stroke. This meta-analysis included 19,464 African American individuals (1,520 with SCT, 17,944 without SCT, and 620 with ischemic stroke) from 4 studies, with a mean (SD) age of 60.0 (13.0) years, (5,257 [27.0%] men and 14,207 [73.0%] women). Researchers found:

  • No differences were found in the distribution of risk factors for ischemic stroke comparing participants with and those without SCT at study visit 1 in each cohort.
  • The crude incidence of ischemic stroke was 2.9 per 1,000 person-years among those with SCT and 3.2 per 1,000 person-years among those without SCT.
  • After stroke risk factors were adjusted for, the hazard ratio of incident ischemic stroke independently associated with SCT in the meta-analysis of all 4 cohorts was 0.80.
  • The results of the meta-analysis were similar to those of individual cohorts, in which the results were also similar.

Citation:

Hyacinth HI, Carty CL, Seals SR, et al. Association of sickle cell trait with ischemic stroke among African Americans. A meta-analysis. [Published online ahead of print April 23, 2018]. JAMA Neurology. doi:10.1001/jamaneurol.2018.0571.

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