Clinical Edge

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Admissions for Psychotic Episodes, Epilepsy Linked

Epilepsia; ePub 2018 Jul 4; Rossi, Kim, et al

An epilepsy admission was independently associated with subsequent hospital readmission for psychotic episodes, even after adjustment for confounding variables, a recent study found. There were 58,278 index admissions for epilepsy, and researchers compared this group against admissions for stroke (n=215,821) and common medical causes (pneumonia, urinary tract infection [UTI], congestive heart failure [CHF], and chronic obstructive pulmonary disease [COPD], n=973,078). Readmission rates for psychotic episodes within 90 days from discharge for index hospitalizations were calculated. They found:

  • Up to 90 days from index admission, there were 683/100,000 readmissions for psychotic episodes in the epilepsy group, 92/100,000 in the stroke group, and 58‐206/100,000 in the medical group.
  • The relative rate of readmission in the epilepsy group was highest in the first 30 days following index admission (311/100,000).
  • Unadjusted hazard ratio (HR) for readmission for psychotic episodes within 1 year in the epilepsy group compared to the stroke group was 6.58 and 4.41, compared to the medical group.
  • Confounding factors most strongly associated with psychosis readmission were documented psychosis history at the time of index admission, younger age, and lower income quartile.


Rossi KC, Kim AM, Jetté N, Yoo JY, Hung K, Dhamoon MS. Increased risk of hospital admission for ICD‐9‐CM psychotic episodes following admission for epilepsy. [Published online ahead of print July 4, 2018]. Epilepsia. doi:10.1111/epi.14508.

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