Vascular risk was associated with prospective cognitive decline in clinically normal older adults, both alone and synergistically with β-amyloid (Aβ) burden, according to a recent study. Furthermore, vascular risk may complement imaging biomarkers in assessing risk of prospective cognitive decline in preclinical Alzheimer disease. In this longitudinal observational study, researchers examined clinically normal older adults from the Harvard Aging Brain Study (n=223, 130 [58.3%] women, mean [SD] age 73.7 [6.0] years, and mean [SD] follow-up time 3.7 [1.2] years). Participants were required to have baseline imaging data (FDG-PET, Aβ-PET, and MRI), baseline medical data to quantify vascular risk, and at least 1 follow-up neuropsychological visit. They found:
- Faster cognitive decline was associated with both a higher Framingham Heart Study-Cardiovascular Disease (FHS-CVD) risk score (β = −0.064) and higher Aβ burden (β = −0.058).
- The interaction of the FHS-CVD risk score and Aβ burden with time was significant (β = −0.040), suggesting a synergistic effect.
- The FHS-CVD risk score remained robustly associated with prospective cognitive decline (β = −0.055), even after adjustment for Aβ burden, hippocampal volume, F-18 labeled positron emission tomography (FDG-PET) uptake, and white matter hyperintensities.
Rabin JS, Schultz AP, Hedden T, et al. Interactive associations of vascular risk and β-amyloid burden with cognitive decline in clinically normal elderly individuals. Findings from the Harvard Aging Brain Study. [Published online ahead print May 21, 2018]. JAMA Neurology. doi:10.1001/jamaneurol.2018.1123.
This Week's Must Reads
Social Cognitive Theory and Physical Activity in MS, Int J MS Care; 2018 May/June; Uszynski, Casey, et al
Wheeled Mobility Device Intervention Found Feasible, Int J MS Care; 2018 May/June; Rice, Isaacs, et al
Somatic Symptoms of Depression/Anxiety in MS, Int J MS Care; 2018 May/June; Jones, Salem, et al
Turning: Important Marker of Gait and Balance in MS, PLoS One; ePub 2018 Jun 7; Adusumilli, Lancia, et al
Autonomic Dysfunction Compared in Patients with MS, Clin Neurophysiol; 2018 Aug; Adamec, Crnošija, et al
Must Reads in Alzheimer's & Cognition
Vascular Risk Linked with Cognitive Decline, JAMA Neurology; ePub 2018 May 21; Rabin, et al
TBI Linked with 2-fold Increase Risk of Dementia, JAMA Neurology; ePub 2018 May 7; Barnes, et al
APOE ε2ε4 Genotype Linked with Cognitive Impairment, Neurology; ePub 2018 May 11; Oveisgharan, et al
Depressive Symptoms, Memory, and the Aging Brain , Neurology; ePub 2018 May 9; Al Hazzouri, et al
Memory Complaints Indicate Higher Dementia Risk, Ann Neurol; 2018 Apr; Arvanitakis, et al