Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Setting Plays Role in Evaluating Cognitive Decline

Alzheimers Dement; ePub 2018 Jan 17; Snitz, et al

Subjective cognitive decline (SCD) is more likely to progress to mild cognitive impairment (MCI) in a memory clinic than the general population, and participants' characteristics vary across settings, according to a recent study. Therefore, study setting should be considered when evaluating SCD as a risk state for MCI and dementia. Older adults presenting at a memory clinic were classified as SCD (n=113) or as noncomplainers (n=82). Participants from a population study were classified as SCD (n=592) and noncomplainers (n=589) based on a memory complaint score. Annual follow-up wasperformed for a mean of 3 years. Researchers found that the adjusted hazard ratio for SCD was 15.97 in the memory clinic vs 1.18 in the population study, where reported “worry” about memory further increased SCD-associated risk for MCI.

Citation:

Snitz BE, Wang T, Cloonan YK, et al. Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting. [Published online ahead of print January 17, 2018]. Alzheimers Dement. doi:10.1016/j.jalz.2017.12.003.

This Week's Must Reads

Pediatric Onset MS Linked with Reduced Parental QOL, Mult Scler; ePub 2018 Aug 30; O’Mahony, et al

Depressive Symptoms Negatively Impact on MS, J Neuropsychiatry Clin Neurosci; ePub 2018 Sep 6; Gill, et al

Evaluation of the MULES Picture Naming Test, J Neurol Sci; ePub 2018 Aug 23; Seay, Akhand, et al

Postrelapse Rehabilitation Use in MS Examined , Int J MS Care; ePub 2018 Sep 5; Asano, Eitzen, et al

Thalamic White Matter in Patients with MS, Hum Brain Mapp; 2018 Oct; Bergsland, et al

Must Reads in Alzheimer's & Cognition

Prevalence and Incidence of AD Dementia Examined, Alzheimers Dement; ePub 2018 Sep 6; Rajan, et al

Link Found Between Ophthalmic Conditions, AD Risk, Alzheimers Dement; ePub 2018 Aug 8; Lee, et al

Spatial Heterogeneity of White Matter Lesions , Neurology; ePub 2018 Aug 3; Habes, et al

Gender and Cognition in Overweight Adults with T2D, Alzheimers Dement; ePub 2018 Jul 4; Espeland, et al

MCI, Dementia Linked with Vascular Risk Factors, Alzheimers Dement; ePub 2018 May 12; Knopman, et al