Subjective cognitive decline (SCD) is more likely to progress to mild cognitive impairment (MCI) in a memory clinic than the general population, and participants' characteristics vary across settings, according to a recent study. Therefore, study setting should be considered when evaluating SCD as a risk state for MCI and dementia. Older adults presenting at a memory clinic were classified as SCD (n=113) or as noncomplainers (n=82). Participants from a population study were classified as SCD (n=592) and noncomplainers (n=589) based on a memory complaint score. Annual follow-up wasperformed for a mean of 3 years. Researchers found that the adjusted hazard ratio for SCD was 15.97 in the memory clinic vs 1.18 in the population study, where reported “worry” about memory further increased SCD-associated risk for MCI.
Snitz BE, Wang T, Cloonan YK, et al. Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting. [Published online ahead of print January 17, 2018]. Alzheimers Dement. doi:10.1016/j.jalz.2017.12.003.
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