Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Prevalence and Incidence of AD Dementia Examined

Alzheimers Dement; ePub 2018 Sep 6; Rajan, et al

The prevalence and incidence of Alzheimer disease (AD) dementia showed substantial variation between 1994 and 2012, but no secular trend, according to a recent study that estimated the prevalence and incidence of AD dementia in a population study based on 2010 US census data. A sample of 2,794 participants with a clinical diagnosis for AD dementia were included. Researchers found:

  • The 2010 census standardized prevalence of AD dementia was 14.5%, and annual incidence was 2.3%.
  • Both prevalence and incidence showed substantial variation over time, but no secular trends.
  • The prevalence of AD dementia did not change significantly from 14.6% in 1994–1997 to 14.7% in 2010–2012.
  • The annual incidence of AD dementia was 2.8% in 1998–2000 and 2.2% in 2004–2006 and remained steady in 2010–2012.
  • The prevalence and incidence among African Americans were approximately twice than those among European Americans.


Rajan KB, Weuve J, Barnes LL, Wilson RS, Evans DA. Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study. [Published online ahead of print September 6, 2018]. Alzheimers Dement. doi:10.1016/j.jalz.2018.07.216.

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