Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Memory Complaints Indicate Higher Dementia Risk

Ann Neurol; 2018 Apr; Arvanitakis, et al

Memory complaints are common in older black and white persons, and relate to cognitive decline, dementia risk, and neurodegenerative pathologies, according to a recent study. A total of 4,015 community‐based persons (28% black; 74% women; mean baseline age = 78 years) were enrolled in 1 of 4 longitudinal cohort studies, and another 2,937 in a population‐based cohort. Researchers found:

  • Baseline memory complaints (n=1,310; 33% of 4,015) were associated with lower cognition and faster decline in all domains, during a mean follow‐up of 6 (SD= 2) years.
  • Persons with memory complaints had higher dementia risk and odds of pathologic Alzheimer disease, neocortical Lewy bodies, and other neurodegenerative pathologies.
  • Results for dementia risk were similar among blacks and whites.
  • Among older persons in the population‐based cohort with similar data, the population‐attributable risk for incident dementia due to memory complaints was 14.0% and did not vary between the black and white groups.


Arvanitakis Z, Leurgans SE, Fleischman DA, et al. Memory complaints, dementia, and neuropathology in older blacks and whites. Ann Neurol. 2018;83(4):718-726. doi:10.1002/ana.25189.

This Week's Must Reads

Midlife Risk Factors Linked to Late-Onset Epilepsy, JAMA Neurology; ePub 2018 Jul 23; Johnson, et al

Nearly 1 Million Adults ≥55 Years Have Epilepsy, Epilepsy Behav; ePub 2018 Aug 2; Sapkota, et al

Incidental Findings Common in Stroke Patients, J Stroke Cerebrovasc Dis; ePub 2018 Aug 2; Doyle, et al

Spatial Heterogeneity of White Matter Lesions , Neurology; ePub 2018 Aug 3; Habes, et al

Poor Sleep Linked to Slow Recovery from TBI, Sleep; ePub 2018 Jul 24; Kalmbach, Conroy, et al

Must Reads in Alzheimer's & Cognition

Spatial Heterogeneity of White Matter Lesions , Neurology; ePub 2018 Aug 3; Habes, et al

Gender and Cognition in Overweight Adults with T2D, Alzheimers Dement; ePub 2018 Jul 4; Espeland, et al

MCI, Dementia Linked with Vascular Risk Factors, Alzheimers Dement; ePub 2018 May 12; Knopman, et al

Vascular Risk Linked with Cognitive Decline, JAMA Neurology; ePub 2018 May 21; Rabin, et al

TBI Linked with 2-fold Increase Risk of Dementia, JAMA Neurology; ePub 2018 May 7; Barnes, et al