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CHD, HF Associated with Increased Dementia Risk

Alzheimers Dement; ePub 2018 Feb 26; Wolters, et al

Coronary heart disease (CHD) and heart failure (HF) are associated with an increased risk of dementia, according to a recent review and meta-analysis. Researchers systematically reviewed the literature and meta-analyzed risk estimates from longitudinal studies reporting the association of CHD or HF with risk of dementia. They identified 16 studies (1,309,483 individuals) regarding CHD, and 7 studies (1,958,702 individuals) about HF and found:

  • A history of CHD was associated with a 27% increased risk of dementia, albeit with considerable heterogeneity across studies (I2 = 80%).
  • HF was associated with 60% increased dementia risk with moderate heterogeneity (I2 = 59%).
  • Among prospective population-based cohorts, pooled estimates were similar (for CHD, RR 1.26 [1.06–1.49], 9 studies; and HF, RR 1.80 [1.41–2.31], 4 studies) and highly consistent (I2 = 0%).


Wolters FJ, Segufa RA, Darweesh SKL, et al. Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta-analysis. [Published online ahead of print February 26, 2018]. Alzheimers Dementia. doi:10.1016/j.jalz.2018.01.007.

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