Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Better CVH Linked with Reduced Cognition Decline

Alzheimers Dementia; ePub 2017 Dec 18; González, et al

Better midlife cardiovascular health (CVH) was associated with higher midlife and reduced decline in cognitive function 20 years later, according to a recent study. However, the benefits of midlife CVH on cognition were stronger for whites than for blacks. These findings suggest that improved midlife CVH may promote enduring cognitive health. Midlife CVH metrics (American Heart Association's Life's Simple 7) were calculated and examined in relation to midlife and 20-year change in cognitive function among 13,270 whites and blacks from the Atherosclerosis Risk in Communities Cohort Study. Researchers used linear mixed models to estimate adjusted associations of midlife CVH with midlife cognitive status and change, and found:

  • Higher midlife (Life's Simple 7) scores and individual metrics, particularly blood pressure and glucose, were associated with better midlife cognition and reduced 20-year decline.
  • Midlife CVH 20-year neuroprotection was more pronounced among whites than blacks.


González HM, Tarraf W, Harrison K, et al. Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results. [Published online ahead of print December 18, 2017]. Alzheimers Dementia. doi:10.1016/j.jalz.2017.11.002.

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