Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

AD, Rest-Activity Rhythm Fragmentation Linked

JAMA Neurology; ePub 2018 Jan 29; Musiek, et al

Preclinical Alzheimer disease (AD) is associated with rest-activity rhythm fragmentation, independent of age or sex, according to a recent study. The presence of circadian rhythm abnormalities in the preclinical phase of AD suggests that circadian dysfunction could contribute to early disease pathogenesis or serve as a biomarker of preclinical disease. This cross-sectional study was conducted using cognitively normal participants who underwent 7 to 14 days of actigraphy in their home environment between 2010 and 2012, in addition to clinical assessment, amyloid imaging with Pittsburgh Compound B (PiB), and cerebrospinal fluid biomarker collection. Data from 189 participants were included; mean (SD) age was 66.6 (8.3) years, and 121 participants (64%) were women. Researchers found:

  • Older age and male sex, in the absence of amyloid pathology, were associated with a significant increase in intradaily variability, a nonparametric measure of rest-activity rhythm fragmentation, as well as decreased amplitude by several measures.
  • After correction for age and sex, the presence of preclinical amyloid plaque pathology, assessed by positive PiB imaging or increasing cerebrospinal fluid phosphorylated-tau to amyloid β 42 ratio, was associated with increased intradaily variability, indicating rest-activity rhythm fragmentation.

Citation:

Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, Ju Y-E S. Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease. [Published online ahead of print January 29, 2018]. JAMA Neurology. doi:10.1001/jamaneurol.2017.4719.

This Week's Must Reads

Pediatric Onset MS Linked with Reduced Parental QOL, Mult Scler; ePub 2018 Aug 30; O’Mahony, et al

Depressive Symptoms Negatively Impact on MS, J Neuropsychiatry Clin Neurosci; ePub 2018 Sep 6; Gill, et al

Evaluation of the MULES Picture Naming Test, J Neurol Sci; ePub 2018 Aug 23; Seay, Akhand, et al

Postrelapse Rehabilitation Use in MS Examined , Int J MS Care; ePub 2018 Sep 5; Asano, Eitzen, et al

Thalamic White Matter in Patients with MS, Hum Brain Mapp; 2018 Oct; Bergsland, et al

Must Reads in Alzheimer's & Cognition

Prevalence and Incidence of AD Dementia Examined, Alzheimers Dement; ePub 2018 Sep 6; Rajan, et al

Link Found Between Ophthalmic Conditions, AD Risk, Alzheimers Dement; ePub 2018 Aug 8; Lee, et al

Spatial Heterogeneity of White Matter Lesions , Neurology; ePub 2018 Aug 3; Habes, et al

Gender and Cognition in Overweight Adults with T2D, Alzheimers Dement; ePub 2018 Jul 4; Espeland, et al

MCI, Dementia Linked with Vascular Risk Factors, Alzheimers Dement; ePub 2018 May 12; Knopman, et al