Higher levels of Alzheimer disease (AD) biomarkers, including among individuals with preclinical AD, lead to earlier driving cessation, a recent study found. Time to driving cessation was examined based on Clinical Dementia Rating (CDR) and AD cerebrospinal fluid biomarkers. 1,795 older adults followed up to 24 years received CDR ratings. A subset (n=591) had cerebrospinal fluid biomarker measurements and was followed up to 17 years. Differences in CDR and biomarker groups as predictors of time to driving cessation were analyzed using Kaplan-Meier curves and Cox proportional models. Researchers found:
- Higher CDR scores and more abnormal biomarker measurements predicted a shorter time to driving cessation.
- Negative functional outcomes of preclinical AD show a non-benign phase of the disease.
Stout SH, Babulal GM, Ma C, et al. Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers. [Published online ahead of print January 9, 2018]. Alzheimers Dement. doi:10.1016/j.jalz.2017.11.011.
This Week's Must Reads
Social Cognitive Theory and Physical Activity in MS, Int J MS Care; 2018 May/June; Uszynski, Casey, et al
Wheeled Mobility Device Intervention Found Feasible, Int J MS Care; 2018 May/June; Rice, Isaacs, et al
Somatic Symptoms of Depression/Anxiety in MS, Int J MS Care; 2018 May/June; Jones, Salem, et al
Turning: Important Marker of Gait and Balance in MS, PLoS One; ePub 2018 Jun 7; Adusumilli, Lancia, et al
Autonomic Dysfunction Compared in Patients with MS, Clin Neurophysiol; 2018 Aug; Adamec, Crnošija, et al
Must Reads in Alzheimer's & Cognition
Vascular Risk Linked with Cognitive Decline, JAMA Neurology; ePub 2018 May 21; Rabin, et al
TBI Linked with 2-fold Increase Risk of Dementia, JAMA Neurology; ePub 2018 May 7; Barnes, et al
APOE ε2ε4 Genotype Linked with Cognitive Impairment, Neurology; ePub 2018 May 11; Oveisgharan, et al
Depressive Symptoms, Memory, and the Aging Brain , Neurology; ePub 2018 May 9; Al Hazzouri, et al
Memory Complaints Indicate Higher Dementia Risk, Ann Neurol; 2018 Apr; Arvanitakis, et al