Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

AD Biomarkers Lead to Earlier Driving Cessation

Alzheimers Dement; ePub 2018 Jan 9; Stout, et al

Higher levels of Alzheimer disease (AD) biomarkers, including among individuals with preclinical AD, lead to earlier driving cessation, a recent study found. Time to driving cessation was examined based on Clinical Dementia Rating (CDR) and AD cerebrospinal fluid biomarkers. 1,795 older adults followed up to 24 years received CDR ratings. A subset (n=591) had cerebrospinal fluid biomarker measurements and was followed up to 17 years. Differences in CDR and biomarker groups as predictors of time to driving cessation were analyzed using Kaplan-Meier curves and Cox proportional models. Researchers found:

  • Higher CDR scores and more abnormal biomarker measurements predicted a shorter time to driving cessation.
  • Negative functional outcomes of preclinical AD show a non-benign phase of the disease.

Stout SH, Babulal GM, Ma C, et al. Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers. [Published online ahead of print January 9, 2018]. Alzheimers Dement. doi:10.1016/j.jalz.2017.11.011.

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