Higher levels of Alzheimer disease (AD) biomarkers, including among individuals with preclinical AD, lead to earlier driving cessation, a recent study found. Time to driving cessation was examined based on Clinical Dementia Rating (CDR) and AD cerebrospinal fluid biomarkers. 1,795 older adults followed up to 24 years received CDR ratings. A subset (n=591) had cerebrospinal fluid biomarker measurements and was followed up to 17 years. Differences in CDR and biomarker groups as predictors of time to driving cessation were analyzed using Kaplan-Meier curves and Cox proportional models. Researchers found:
- Higher CDR scores and more abnormal biomarker measurements predicted a shorter time to driving cessation.
- Negative functional outcomes of preclinical AD show a non-benign phase of the disease.
Stout SH, Babulal GM, Ma C, et al. Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers. [Published online ahead of print January 9, 2018]. Alzheimers Dement. doi:10.1016/j.jalz.2017.11.011.
This Week's Must Reads
MS Risk Factors Contribute to Onset Heterogeneity, Mult Scler Relat Disord; ePub 2018 Dec 3; Briggs, et al
Severe Fatigue in MS Predicts EDSS Worsening, Mult Scler; ePub 2018 Dec 3; Vaughn, et al
Cerebrospinal Fluid Biomarkers and MS Severity, Mult Scler Relat Disord; ePub 2018 Dec 5; Masvekar, et al
Research-to-Practice Gaps in Multiple Sclerosis, Int J MS Care; ePub 2018 Nov 27; Walker, et al
Head Trauma, Autoimmune Diseases: No Link with MS , Neuroepidemiol; ePub 2018 Nov 26; Abdollahpour, et al
Must Reads in Alzheimer's & Cognition
Vegetable/Fruit Intake Benefits Cognitive Function, Neurology; ePub 2018 Nov 21; Yuan, Fondell, et al
Alzheimer Dementia and Age-Related Neuropathologies, Ann Neurol; ePub 2018 Nov 12; Boyle, Yu, et al
Higher Cortisol Linked with Lower Brain Volume, Neurology; ePub 2018 Oct 24; Echouffo-Tcheugui, et al
Hypertension, Obesity, Cognitive Decline Examined , Alzheimers Dement; ePub 2018 Oct 24; Clark, et al
Racial/Ethnic Estimates of AD and Related Dementias, Alzheimers Dement; ePub 2018 Sep 19; Matthews, et al