15 million persons in the US will be living with mild cognitive impairment due to Alzheimer disease (AD) or clinical AD by 2060, a recent study predicts. Furthermore, since large numbers of persons are living with preclinical AD, these results underscore the need for secondary preventions for persons with existing AD brain pathology who are likely to develop clinical disease during their lifetimes, as well as primary preventions for persons without preclinical disease. Researchers used a multistate model incorporating biomarkers for preclinical AD with US population projections. They found:
- Approximately 6.08 million Americans had either clinical AD or mild cognitive impairment due to AD in 2017 and that will grow to 15 million by 2060.
- In 2017, 46.7 million Americans had preclinical AD (amyloidosis, neurodegeneration, or both), although many may not progress to clinical disease during their lifetimes.
- Primary and secondary preventions have differential impact on future disease burden.
Brookmeyer R, Abdalla N, Kawas CH, Corrada MM. Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States. [Published online ahead of print December 6, 2017]. Alzheimers Dement. doi:10.1016/j.jalz.2017.10.009.
This Week's Must Reads
Social Cognitive Theory and Physical Activity in MS, Int J MS Care; 2018 May/June; Uszynski, Casey, et al
Wheeled Mobility Device Intervention Found Feasible, Int J MS Care; 2018 May/June; Rice, Isaacs, et al
Somatic Symptoms of Depression/Anxiety in MS, Int J MS Care; 2018 May/June; Jones, Salem, et al
Turning: Important Marker of Gait and Balance in MS, PLoS One; ePub 2018 Jun 7; Adusumilli, Lancia, et al
Autonomic Dysfunction Compared in Patients with MS, Clin Neurophysiol; 2018 Aug; Adamec, Crnošija, et al
Must Reads in Alzheimer's & Cognition
Vascular Risk Linked with Cognitive Decline, JAMA Neurology; ePub 2018 May 21; Rabin, et al
TBI Linked with 2-fold Increase Risk of Dementia, JAMA Neurology; ePub 2018 May 7; Barnes, et al
APOE ε2ε4 Genotype Linked with Cognitive Impairment, Neurology; ePub 2018 May 11; Oveisgharan, et al
Depressive Symptoms, Memory, and the Aging Brain , Neurology; ePub 2018 May 9; Al Hazzouri, et al
Memory Complaints Indicate Higher Dementia Risk, Ann Neurol; 2018 Apr; Arvanitakis, et al