Literature Monitor

Women with Migraine Have Lower T2D Risk

JAMA Neurology; ePub 2018 Dec 17; Fagherazzi, et al


Women with active migraine have a lower risk of developing type 2 diabetes (T2D), according to a recent study, and a decrease in active migraine prevalence prior to diabetes diagnosis. Researchers used data from a prospective population-based study initiated in 1990 on a cohort of women born between 1925 and 1950. From eligible women in the study, researchers included those who completed a 2002 follow-up questionnaire with information available on migraine. They then excluded prevalent cases of T2D, leaving a final sample of women who were followed up between 2004 and 2014. All potential occurrences of T2D were identified through a drug reimbursement database. They found:

  • From the 98,995 women in the study, 76,403 women completed the 2002 follow-up survey.
  • Of these, 2156 were excluded because they had T2D, leaving 74,247 women.
  • During 10 years of follow-up, 2372 incident T2D cases occurred.
  • A lower risk of T2D was observed for women with active migraine compared with women with no migraine history (univariate hazard ratio, 0.80, multivariable-adjusted hazard ratio, 0.7).

Fagherazzi G, El Fatouhi D, Fournier A, et al. Associations between migraine and type 2 diabetes in women: Findings from the E3N Cohort Study. [Published online ahead of print December 17, 2018]. JAMA Neurology . doi:10.1001/jamaneurol.2018.3960.

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