Literature Review

Does Deep Brain Stimulation of ANT Provide Sustained Efficacy and Safety?

Long-term efficacy and safety results of deep brain stimulation of ANT reported



Deep brain stimulation of the anterior nucleus of the thalamus (ANT) for treatment of localization-related epilepsy showed sustained efficacy and safety in this long-term follow-up of the SANTE trial. This study shows that ANT stimulation was associated with seizure frequency reduction rate of 69% at 5 years. The study also reported that 16% of subjects were seizure-free for ≥6 months during the 5 years of follow-up. ANT stimulation was associated with a 34% serious device-related adverse event rate at 5 years.

Salanova V, Witt T, Worth R, et al; SANTE Study Group. Long-term efficacy and safety of thalamic stimulation for drug resistant partial epilepsy. Neurology. 2015;84(10):1017-1025.

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