Analyzing infraslow amplitude modulations may help clinicians better understand changes in intracranial EEG readings over the long-term and help researchers develop better algorithms to forecast the onset of seizures, according to a report published in Epilepsia.
- Investigators from Yale-New Haven Hospital collected intracranial EEG readings from 13 adult patients with medically refractory epilepsy.
- To derive infraslow envelope correlations, they estimated magnitude-squared coherence at <0.15 Hz of EEG frequency band power time series for all electrode contact pairs.
- Infraslow envelope magnitude-squared coherence increased significantly after patients had their antiepileptic drugs tapered; it also increased at night and decreased during the day.
Joshi RB, Duckrow RB, Goncharova II, et al. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia. 2018;59:2075-2085.