Patients with tuberous sclerosis complex (TSC) are at higher than average risk of developing epilepsy if they exhibit several systemic disease manifestations, according to a recent analysis of the TSC Natural History Database. After factoring out confounding variables like age, gender, and TSC mutation, Anna Jeong and Michael Wong of Washington University School of Medicine found that cardiac rhabdomyomas, retinal hamartomas, renal cysts, renal angiomyolipomas, shagreen patches, and facial angiofibromas increased the likelihood of TSC patients developing epilepsy.
Jeong A, Wong M. Systemic disease manifestations associated with epilepsy in tuberous sclerosis complex. Epilepsia. 2016;57(9):1443-1449.