Literature Review

Which nonvenous drugs exhibit the best efficacy data for treatment of acute convulsive seizures?

A meta-analysis of 16 studies



This meta-analysis examined 16 studies of nonvenous drugs used in randomized controlled trials for the treatment of acute convulsive seizures and convulsive status epilepticus. Intramuscular midazolam was superior to other nonvenous medications for time to seizure termination after administration, time to seizure cessation after arrival at the hospital, and the time to initiate treatment. Intranasal midazolam was found most effective for seizure cessation within 10 minutes of administration.

Arya R, Kothari H, Zhang Z, Han B, Horn PS, Glauser TA. Efficacy of nonvenous medications for acute convulsive seizures: a network meta-analysis. Neurology 2015: doi: 10.1212/WNL.0000000000002142.

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