Literature Review

What are the obstetric complications of pregnant women with epilepsy?

A systematic review and meta-analysis of the association between epilepsy and reproductive outcomes



Researchers identified 38 studies of pregnant women with epilepsy and compared women with epilepsy vs women without epilepsy. They found that pregnant women with epilepsy had increased odds of:

  • Spontaneous miscarriage
  • Antepartum hemorrhage
  • Post-partum hemorrhage
  • Hypertensive disorders
  • Induction of labor
  • Cesarean section
  • Preterm birth
  • Fetal growth restriction

The authors state that these increased risks should be taken into account when counseling women with epilepsy.

Viale L, Allotey J, Cheong-See F, et al; EBM CONNECT Collaboration. Epilepsy in pregnancy and reproductive outcomes: a systematic review and meta-analysis. Lancet. 2015; doi:10.1016/S0140-6736(15)00045-8.

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